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Currently, both domestic and international studies have investigated the correlations between GLP-1RAs and medullary thyroid cancer, pancreatic cancer, colorectal cancer, prostate cancer, breast cancer, reproductive system tumors, and other oncological disorders

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Considering the high constitutive activity of GHSR, antagonists or inverse agonists of the GHSR have been proposed as potential approaches (126)

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TRPV1, known for its thermosensitive and polymodal nociceptor properties, is expressed in sensory neurons and is activated by stimuli such as capsaicin (CAP) and protons 20